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Venlafaxine discontinued in us u. 2000. The data indicated that risk of the clinical syndrome serotonin (SSS) and of death is higher in patients who are taking high-dose SSRIs and in patients taking an SSRI when compared with those taking a low-dose or placebo drug. It may be possible that if a patient taking SSRI is treated with other medications, such as monoamine oxidase inhibitors, that the development of SSS may be blocked. As a result, the risk of hospitalization and death from SSS may be reduced. However, other factors also seem to increase the risk of SSS or may affect the response to treatment. At present there is no convincing evidence that a causal relationship exists between SSS and SSRIs. As such, the risk-benefit balance and possible role of other therapeutic choices must be considered. As there is no good evidence to suggest that any individual drug has the power to prevent one or more other serious cardiovascular risks associated with antidepressant treatment, the Advisory Committee suggests that risk-benefit balance should be reviewed and that there should be continued and more accurate awareness of the relative risks and benefits of the possible treatment options. The guidelines set out a series of recommendations which will enable GP's and other health professionals to advise patients in a more complete and accurate way than is currently possible, if they so wish, as soon evidence is available. The Guidelines on Management and Prevention of Cardiovascular Risk in Major Depressive Disorder are available from the GP Practice information Service (see links). 1. How is depression diagnosed? the diagnosis necessary for clinical management? 1.1. Diagnosis can be carried out in most general practices and hospitals by using criteria previously developed Dr Peter Gordon (Dr is a Clinical Professor of Psychiatry at King's College London). This procedure relies on the presence of four diagnostic criteria, which vary with age but generally include one or two of the following: marked dysphoria (anhedonia) that begins around the 3rd month of pregnancy and disappears by 6 months; profound depressive mood, occurring in response to some event or stimulation (including loss of interest in daily activities), and occurring to an extremely high degree in individuals (often referred to as high-risk groups) who have a fa